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Chem Commun (Camb). 2009 Oct 7;(37):5527-9. doi: 10.1039/b913317h. Epub 2009 Aug 11.

Synthesis and preliminary biological evaluations of [18F]-1-deoxy-1-fluoro-scyllo-inositol.

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1
PET Centre, Centre for Addiction and Mental Health, 250 College St., Toronto, ON, Canada M5T 1R8. neil.vasdev@camhpet.ca

Abstract

A novel PET radiotracer, [18F]-1-deoxy-1-fluoro-scyllo-inositol, was synthesized via a one-pot reaction in 16 +/- 3% uncorrected radiochemical yield within 80 minutes; although this compound revealed low brain penetration it shows promise in rodent tumour models for breast cancer imaging.

PMID:
19753345
DOI:
10.1039/b913317h
[Indexed for MEDLINE]
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