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Arch Ophthalmol. 2009 Sep;127(9):1168-74. doi: 10.1001/archophthalmol.2009.198.

Change in area of geographic atrophy in the Age-Related Eye Disease Study: AREDS report number 26.

Collaborators (299)

Lindblad AS, Lloyd PC, Clemons TE, Gensler GR, Ferris FL 3rd, Klein ML, Armstrong JR, Kassoff A, Kassoff J, Buehler J, Eglow M, Silverman S, Mehu M, Kieval S, Kaufman F, Mairs M, Graig B, Quattrocchi A, Jones D, Locatelli J, Ruby A, Capone A Jr, Garretson B, Hassan T, Trese MT, Williams GA, Regan V, Manatrey P, Streasick P, Szydlowski L, McIver F, Bridges C, Stanley C, Cumming K, Mitchell B, Holloway J, Lewis B, Zajechowski M, Margherio RR, Cox MS, Werner JC, Falk R, Siedlak P, Neubert C, Klein ML, Stout JT, Lauer AK, Beardsley C, Anderson H, Wallace P, Smith G, Howard S, Dreyer RF, Ma C, Chenoweth RG, Zilis JD, O'Malley A, Robertson JE, Wilson DJ, Johnson M, Rice P, Daniel H, Crider H, Parker S, Sherman K, Martin DF, Aaberg TM Sr, Hubbard GB, Garcia E, Curtis LT, DeLeon A, Myles B, Yi H, Capone A Jr, Lambert M, Meredith T, Aaberg TM Jr, Sternberg P Jr, Saperstein D, Lim JI, Stribling B, Ju B, Armiger D, Gilman J, Jordan D, Strittman S, Swords R, Orth DH, Flood TP, Civantos J, deBustros S, Packo KH, Merrill PT, Cohen JA, Chow D, Figliulo C, Morrison C, Bryant DA, Doherty D, McVicker M, Drefcinski T, Seddon JM, Pinnolis MK, Sachdeva M, Taytsel T, Burton I, Walsh D, Callahan C, Evans C, Snow KK, Jones-Devonish DA, Crouse VD, Rosenberg J, Davis N, Dubois-Moran J, Chew EY, Csaky K, Ferris FL 3rd, Shimel KH, Woods MA, Cunningham D, Kuehl EM, Palmer M, Babilonia-Ayukawa G, Foster GE, Kim YJ, Kivitz IJ, Koutsandreas D, LaReau A, Mercer RF, Nashwinter R, Rowan J, Short G, McCarthy SA, Ciatto PF, Ayres LM, Goodman L, Lopez P, Perry C, Randalls A, Friberg TR, Eller AW, Gorin MB, Mack B, Curtin DY, Ostroska PP, Fijewski E, Alexander J, Nixon S, Paine MK, Corbin PS, Warnicki J, Bressler SB, Bressler NM, Cassel G, Finkelstein D, Goldberg M, Haller JA, Ratner L, Schachat AP, Sherman SH, Sunness JS, Schenning S, Sackett C, Cain D, Emmert D, Herring M, McDonald J, Falk R, Wheeler S, Mcmillan M, George T, Elman MJ, Ballinger R, Betancourt A, Herr M, Lammlein J, Raden RZ, Seff R, Shuman M, Starr J, Firestone D, Sloan M, Sotirakos P, Cain T, Mathews T, Glasser D, Hirsch D, Killingsworth D, Kohlhepp P, Ringrose C, Carrigan A, Chandra SR, Gottlieb JL, Ip MS, Klein R, Nork TM, Stevens TS, Blodi BA, Altaweel M, Klein BE, Davis MD, Olson M, Skoldberg A, Christianson E, Soderling B, Perry-Raymond JR, Burke K, Knutson G, Peterson J, Krolnik D, Harrison R, Somers G, Myers FL, Wallow I, Olsen TW, Bresnik G, De Venecia G, Perkins T, Walker W, Miller JL, Blatz M, Neider M, Wabers HD, Weber G, Amspaugh B, Buechner J, Myers HE, Davis MD, Klein BE, Klein R, Blodi B, Danis R, Hubbard L, Neider M, Vargo P, Wabers HD, Armstrong J, Benz W, Dohm KL, Fink C, Harding T, Hurtenbach C, Lang K, Reed S, Fisher MR, Gangnon R, Lee LY, Carr A, Baliker J, Kastorff L, Robinson N, Glander KE, Surfus J, Ansay S, Magli YL, Badal D, Craanen S, Elledge J, Esser B, Geithman PL, Miner KD, Reimers J, Webster M, Gai C, King W, Osterby K, Onofrey J, Schleicher RL, Miller DT, Sowell AL, Gunter EW, Bowman BA, Lindblad AS, Milton RC, Clemons TE, Gensler G, Rankin M, Henning A, Entler G, McBee W, Watson V, Davis C, Stine E, Berlin SH, Thotapally K, Jackson M, Tomlin K, Pallas S, Scholl PR, Mengers SA, Ederer F, Anand R, Roberts K, Ferris FL 3rd, Sperduto RD, Kurinij N, Chew EY, SanGiovanni JP.

Abstract

OBJECTIVE:

To characterize progression of geographic atrophy (GA) associated with age-related macular degeneration in AREDS as measured by digitized fundus photographs.

METHODS:

Fundus photographs from 181 of 4757 AREDS participants with a GA area of at least 0.5 disc areas at baseline or from participants who developed bilateral GA during follow-up were scanned, digitized, and evaluated longitudinally. Geographic atrophy area was determined using planimetry. Rates of progression from noncentral to central GA and of vision loss following development of central GA included the entire AREDS cohort.

RESULTS:

Median initial lesion size was 4.3 mm(2). Average change in digital area of GA from baseline was 2.03 mm(2) (standard error of the mean, 0.24 mm(2)) at 1 year, 3.78 mm(2) (0.24 mm(2)) at 2 years, 5.93 mm(2) (0.34 mm(2)) at 3 years, and 1.78 mm(2) (0.086 mm(2)) per year overall. Median time to developing central GA after any GA diagnosis was 2.5 years (95% confidence interval, 2.0-3.0). Average visual acuity decreased by 3.7 letters at first documentation of central GA, and by 22 letters at year 5.

CONCLUSIONS:

Growth of GA area can be reliably measured using standard fundus photographs that are digitized and subsequently graded at a reading center. Development of GA is associated with subsequent further growth of GA, development of central GA, and loss in central vision.

PMID:
19752426
PMCID:
PMC6500457
DOI:
10.1001/archophthalmol.2009.198
[Indexed for MEDLINE]
Free PMC Article

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