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Rheumatology (Oxford). 2009 Dec;48(12):1512-4. doi: 10.1093/rheumatology/kep249. Epub 2009 Sep 14.

Impact of primary Sjogren's syndrome on smell and taste: effect on quality of life.

Author information

1
North West Wales NHS Trust, Bangor University, Bangor, UK.

Abstract

OBJECTIVES:

To assess the prevalence of abnormal smell and taste perception in people with primary SS and the effect on quality of life (QoL).

METHODS:

Twenty-eight participants with SS and 37 controls were enrolled in a cohort-matched, prospective, cross-sectional study. Smell and taste thresholds were measured using standardized, validated tests. QoL was assessed by the Short Form 12 (SF-12).

RESULTS:

Smell threshold was reduced by 1 point (P = 0.002; 95% CI 0.35, 1.54) and taste threshold was reduced by 3.5 points (P < 0.001; 95% CI 1.80, 5.22) in the SS group compared with controls. The physical and mental components of SF-12 were reduced by 14.2 points (P < 0.001; 95% CI 9.47, 19.02) and 7.5 points (P = 0.002; 95% CI 2.97, 12.02), respectively, in the SS group compared with controls. Taste threshold was significantly correlated with both the physical (r = 0.48; P < 0.001) and the mental (r = 0.30; P = 0.015) components of SF-12. Smell threshold correlated with the physical (r = 0.457; P < 0.001), but not the mental component (r = 0.154; P = 0.222) of SF-12.

CONCLUSIONS:

Clinically important impairment of chemosensory perception occurred in the SS group compared with age- and gender-matched controls. Assessment using SF-12 suggests that this impairment contributed to the reduced health-related QoL that characterized these individuals.

PMID:
19752179
DOI:
10.1093/rheumatology/kep249
[Indexed for MEDLINE]

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