Send to

Choose Destination
See comment in PubMed Commons below
Mol Phylogenet Evol. 2009 Dec;53(3):1049-54. doi: 10.1016/j.ympev.2009.09.003. Epub 2009 Sep 12.

Transthyretin gene (TTR) intron 1 elucidates crocodylian phylogenetic relationships.

Author information

  • 1Texas Tech University Health Sciences Center, Dept of Cell Physiology and Molecular Biophysics, 3601 4th St MS 6551, Lubbock, TX 79430-6551, USA.


Transthyretin (TTR) is an attractive candidate for use in phylogenetic analysis because it is a short, single-copy nuclear gene with regions that are highly conserved across evolutionarily-divergent organisms from Xenopus laevis to Homo sapiens. To explore its utility as a phylogenetic marker, the complete intron one region (789-805 bp) was sequenced in 22 crocodylian species. Detailed analyses of intron 1 resolved the three expected lineages, Alligatorids, Crocodylids, and Gavialids, and offered additional evidence for the utility of synapomorphic indels in elucidating higher-level phylogenetic relationships. When used in conjunction with other genetic and morphological data sets, intron 1 should be a valuable tool in the investigation of other closely related taxa.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk