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Biochim Biophys Acta. 2010 Oct;1802(10):860-71. doi: 10.1016/j.bbadis.2009.09.008. Epub 2009 Sep 12.

Animal models reveal role for tau phosphorylation in human disease.

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1
Alzheimer's and Parkinson's Disease Laboratory, Brain and Mind Research Institute, University of Sydney, 100 Mallett Street, Camperdown, New South Wales 2050, Australia. jgoetz@med.usyd.edu.au

Abstract

Many proteins that are implicated in human disease are posttranslationally modified. This includes the microtubule-associated protein tau that is deposited in a hyperphosphorylated form in brains of Alzheimer's disease patients. The focus of this review article is on the physiological and pathological phosphorylation of tau; the relevance of aberrant phosphorylation for disease; the role of kinases and phosphatases in this process; its modeling in transgenic mice, flies, and worms; and implications of phosphorylation for therapeutic intervention.

PMID:
19751831
DOI:
10.1016/j.bbadis.2009.09.008
[Indexed for MEDLINE]
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