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Proteomics. 2009 Oct;9(20):4726-30. doi: 10.1002/pmic.200900176.

Upc2p-associated differential protein expression in Candida albicans.

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Departments of Clinical Pharmacy, Pharmaceutical Sciences, and Pediatrics, Colleges of Pharmacy and Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.


The gain-of-function mutation G648D in UPC2 causes ERG11 up-regulation and increased fluconazole resistance in Candida albicans. In this study, we performed 2-DE and PMF to identify proteomic alterations in an ERG11-overexpressing fluconazole-resistant C. albicans clinical isolate compared with its fluconazole-susceptible parent strain. We identified 23 differentially expressed proteins, and among them, seven became differentially expressed in a C. albicans wild-type strain after the introduction of a UPC2 allele carrying this mutation. These Upc2p-regulated proteins may contribute to fluconazole resistance in C. albicans.

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