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Environ Health Perspect. 2009 Sep;117(9):1393-6. doi: 10.1289/ehp.0900672. Epub 2009 Jun 4.

Pesticide exposure and hypertensive disorders during pregnancy.

Author information

1
Social and Scientific Systems, Inc., 1009 Slater Road, Durham, NC 27703, USA. saldana@niehs.nih.gov

Abstract

BACKGROUND:

Hypertensive disorders of pregnancy, including pregnancy-induced hypertension (PIH) and preeclampsia (PE), complicate 2-8% of pregnancies. Few studies have examined environmental risk factors in relation to these conditions.

OBJECTIVES:

Our goal was to examine whether pesticide exposure during pregnancy was associated with hypertensive disorders of pregnancy.

METHODS:

We analyzed self-reported data from 11,274 wives of farmers enrolled in the Agricultural Health Study (AHS) between 1993 and 1997. Using logistic regression models, we estimated the adjusted odds ratios (AORs) for PIH and PE associated with pesticide-related activities during the first trimester of pregnancy.

RESULTS:

First-trimester residential and agricultural activities with potential exposure to pesticides were associated with both PIH [residential AOR = 1.27; 95% confidence interval (CI), 1.02-1.60; agricultural AOR = 1.60; 95% CI, 1.05-2.45] and PE (residential AOR = 1.32; 95% CI, 1.02-1.70; agricultural AOR = 2.07; 95% CI, 1.34-3.21).

CONCLUSIONS:

Exposure to pesticides during pregnancy may increase the risk of hypertensive disorders of pregnancy. Laboratory research may provide insights into relationships between pesticide exposure and hypertensive diseases of pregnancy.

KEYWORDS:

pesticide exposure; preeclampsia; pregnancy-induced hypertension

PMID:
19750103
PMCID:
PMC2737015
DOI:
10.1289/ehp.0900672
[Indexed for MEDLINE]
Free PMC Article

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