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Nat Neurosci. 2009 Oct;12(10):1222-3. doi: 10.1038/nn.2384. Epub 2009 Sep 13.

Selective suppression of hippocampal ripples impairs spatial memory.

Author information

1
Laboratoire de Physiologie de la Perception et de l'Action, Collège de France, CNRS, Paris, France.

Abstract

Sharp wave-ripple (SPW-R) complexes in the hippocampus-entorhinal cortex are believed to be important for transferring labile memories from the hippocampus to the neocortex for long-term storage. We found that selective elimination of SPW-Rs during post-training consolidation periods resulted in performance impairment in rats trained on a hippocampus-dependent spatial memory task. Our results provide evidence for a prominent role of hippocampal SPW-Rs in memory consolidation.

PMID:
19749750
DOI:
10.1038/nn.2384
[Indexed for MEDLINE]

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