Format

Send to

Choose Destination
J Occup Environ Med. 2009 Oct;51(10):1177-84. doi: 10.1097/JOM.0b013e3181b68cef.

Risk of mesothelioma and occupational exposure to asbestos and man-made vitreous fibers: evidence from two case-control studies in Montreal, Canada.

Author information

1
INRS-Institut Armand-Frappier, Unit of Epidemiology and Biostatistics, Laval, Quebec, Canada. javier.pintos@iaf.inrs.ca

Abstract

OBJECTIVE:

To examine the effects of exposure to occupational asbestos and man-made vitreous fibers (MMVF) across a wide range of occupations on risk of mesothelioma.

METHODOLOGY:

Two population-based case-control studies (1979-1986 and 1996-2001) provided 35 histologically confirmed mesothelioma cases and 1965 controls. A detailed job history was obtained to evaluate occupational exposure to many agents, including asbestos and MMVF.

RESULTS:

The mesothelioma odds ratio for exposure to any asbestos type was 3.7 (95% confidence interval = 1.7 to 7.8). The subset exposed to amphibole fibers experienced an odds ratio = 7.0 (95% confidence interval = 2.7 to 18.5). Effects of MMVF could not be disentangled from those of asbestos.

DISCUSSION:

In workers with exposure levels lower than in most historical cohort studies and across a wide range of industries, a strong association was found between asbestos, especially when it was amphibole, and mesothelioma.

PMID:
19749604
DOI:
10.1097/JOM.0b013e3181b68cef
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center