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Circ J. 2009 Nov;73(11):2125-34. Epub 2009 Sep 14.

Antioxidant, EUK-8, prevents murine dilated cardiomyopathy.

Author information

1
Department of Research and Development, Anti-Aging Science, Co Ltd, United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.

Abstract

BACKGROUND:

Mice lacking manganese-superoxide dismutase (Mn-SOD) activity exhibit the typical pathology of dilated cardiomyopathy (DCM). In the present study, presymptomatic and symptomatic mutant mice were treated with the SOD/catalase mimetic, EUK-8.

METHODS AND RESULTS:

Presymptomatic heart/muscle-specific Mn-SOD-deficient mice (H/M-Sod2(-/-)) were treated with EUK-8 (30 mg x kg(-1) . day(-1)) for 4 weeks, and then cardiac function and the reactive oxygen species (ROS) production in their heart mitochondria were assessed. EUK-8 treatment suppressed the progression of cardiac dysfunction and diminished ROS production and oxidative damage. Furthermore, EUK-8 treatment effectively reversed the cardiac dilatation and dysfunction observed in symptomatic H/M-Sod2(-/-) mice. Interestingly, EUK-8 treatment repaired a molecular defect in connexin43.

CONCLUSIONS:

EUK-8 treatment can prevent and cure murine DCM, so SOD/catalase mimetic treatment is proposed as a potential therapy for DCM.

PMID:
19749480
[Indexed for MEDLINE]
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