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Genomics. 1990 Aug;7(4):602-6.

Accurate assessment of intragenic recombination frequency within the Duchenne muscular dystrophy gene.

Author information

1
Paediatric Research Unit, United Medical School Guy's Hospital, London, United Kingdom.

Abstract

Polymorphic loci that lie at the two extremities of the Duchenne/Becker muscular dystrophy (DMD/BMD) gene have been used to estimate intragenic recombination rates. Multipoint linkage analysis of the CEPH panel of families suggests a total intragenic recombination frequency of nearly 0.12 (confidence intervals 0.041-0.226) over the genomic length of approximately 2 Mb.

PMID:
1974880
DOI:
10.1016/0888-7543(90)90205-9
[Indexed for MEDLINE]

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