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Mol Cell. 2009 Sep 11;35(5):543-5. doi: 10.1016/j.molcel.2009.08.010.

Amino acid signaling to TOR activation: Vam6 functioning as a Gtr1 GEF.

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1
Department of Pharmacology, Moores Cancer Center, University of California, San Diego, La Jolla, 92093, USA.

Abstract

In this issue of Molecular Cell, Binda et al. identify Vam6/Vps39 as a guanine nucleotide exchange factor for Gtr1, a Rag family GTPase, to promote TORC1 activation in response to amino acids.

PMID:
19748348
DOI:
10.1016/j.molcel.2009.08.010
[Indexed for MEDLINE]
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