Format

Send to

Choose Destination
Phytomedicine. 2010 Apr;17(5):379-82. doi: 10.1016/j.phymed.2009.08.002. Epub 2009 Sep 11.

Antiprotozoal activity of betulinic acid derivatives.

Author information

1
Unidad de Biotecnología, Centro de Investigación Científica de Yucatán, Calle 43, No. 130, Col. Chuburná, Mérida, Yucatán 97200, México.

Abstract

Betulinic acid (1), isolated from the crude extract of the leaves of Pentalinon andrieuxii (Apocynaceae), together with betulinic acid acetate (2), betulonic acid (3), betulinic acid methyl ester (4), and betulin (5) were evaluated for their antiprotozoal activity. The results showed that modifying the C-3 position increases leishmanicidal activity while modification of the C-3 and C-28 positions decreases trypanocidal activity.

PMID:
19748254
DOI:
10.1016/j.phymed.2009.08.002
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center