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Mol Cell Endocrinol. 2010 Apr 29;318(1-2):34-43. doi: 10.1016/j.mce.2009.08.031. Epub 2009 Sep 10.

Sensory and sympathetic nervous system control of white adipose tissue lipolysis.

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1
Department of Biology and Center for Behavioral Neuroscience, Georgia State University, Atlanta, GA 30302-4010, USA. bartness@gsu.edu

Abstract

Circulating factors are typically invoked to explain bidirectional communication between the CNS and white adipose tissue (WAT). Thus, initiation of lipolysis has been relegated primarily to adrenal medullary secreted catecholamines and the inhibition of lipolysis primarily to pancreatic insulin, whereas signals of body fat levels to the brain have been ascribed to adipokines such as leptin. By contrast, evidence is given for bidirectional communication between brain and WAT occurring via the sympathetic nervous system (SNS) and sensory innervation of this tissue. Using retrograde transneuronal viral tract tracers, the SNS outflow from brain to WAT has been defined. Functionally, sympathetic denervation of WAT blocks lipolysis to a variety of lipolytic stimuli. Using anterograde transneuronal viral tract tracers, the sensory input from WAT to brain has been defined. Functionally, these WAT sensory nerves respond electrophysiologically to increases in WAT SNS drive suggesting a possible neural negative feedback loop to regulate lipolysis.

PMID:
19747957
PMCID:
PMC2826518
DOI:
10.1016/j.mce.2009.08.031
[Indexed for MEDLINE]
Free PMC Article
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