Send to

Choose Destination
See comment in PubMed Commons below
Eur J Med Chem. 2009 Nov;44(11):4778-82. doi: 10.1016/j.ejmech.2009.07.021. Epub 2009 Jul 30.

Synthesis and antimalarial activity of new atovaquone derivatives.

Author information

  • 1Universit√© Paul Sabatier Toulouse III, Facult√© de Pharmacie, Laboratoire de Chimie Pharmaceutique, 31062 Toulouse Cedex 09, France.


In this paper we describe the design and synthesis of 18 derivatives of the antimicrobial atovaquone which were substituted at the 3-hydroxy group by ester and ether functions. The compounds were evaluated in vitro for their activity against the growth of Plasmodium falciparum, the malaria causing parasite. All the compounds showed potent activity, with IC(50) values in the range of 1.25-50 nM, comparable to those of atovaquone and much higher than chloroquine or quinine.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk