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Antioxid Redox Signal. 2010 Apr 1;12(7):881-92. doi: 10.1089/ars.2009.2878.

Threading the needle: getting selenocysteine into proteins.

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1
Department of Microbiology, Molecular Genetics, and Immunology, Graduate School of Biomedical Sciences, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 675 Hoes Lane, Piscataway, NJ 08854, USA.

Abstract

The co-translational incorporation of selenocysteine (Sec) requires that UGA be recognized as a sense rather than a nonsense codon. This is accomplished by the concerted action of a Sec insertion sequence (SECIS) element, SECIS binding protein 2, and a ternary complex of the Sec specific elongation factor, Sec-tRNA(Sec), and GTP. The mechanism by which they alter the canonical protein synthesis reaction has been elusive. Here we present an overview of the mechanistic perspective on Sec incorporation, highlighting recent advances in the field.

PMID:
19747061
PMCID:
PMC2864665
DOI:
10.1089/ars.2009.2878
[Indexed for MEDLINE]
Free PMC Article
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