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J Glaucoma. 2009 Sep;18(7):501-5. doi: 10.1097/IJG.0b013e318193c2be.

Myopia affects retinal nerve fiber layer measurements as determined by optical coherence tomography.

Author information

1
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami School of Medicine, 900 NW 17th Street,Miami, FL 33136, USA.

Abstract

PURPOSE:

To determine whether increasing myopia is associated with thinner peripapillary retinal nerve fiber layer (RNFL) when measured by Stratus optical coherence tomography (OCT).

DESIGN:

Observational cross-sectional study.

METHODS:

Normal subjects with myopia underwent refractometry, axial length measurement (IOL Master), optic nerve examination, and OCT (12 fast RNFL scans/eye). The more myopic eye was chosen as the study eye. Correlation coefficients were calculated for demographic and optic disk characteristics, and degree of myopia.

RESULTS:

Mean age (n=27) was 34+/-8 years (range: 23 to 54). Mean cup-to-disk ratio was 0.38 with 41% large and 59% medium disk size. Eight subjects had peripapillary atrophy and 6 had disk tilt. Mean spherical equivalent was -5.40 D (range: -1.25 to -11.25), with mean axial length of 25.65 mm (range: 22.63 to 27.92). No significant associations were found between RNFL thickness and age (P=0.20), sex, disk size, cup-to-disk ratio, tilt, or peripapillary atrophy. RNFL thickness decreased with higher axial length (overall R=-0.70, P<0.001, superior R=-0.60, P=0.001, and inferior R=-0.60, P=0.001), and higher spherical equivalent (overall R=-0.52, P=0.005, superior R=-0.41, P=0.03, and inferior R=-0.45, P=0.02). Overall RNFL thickness decreased 7 mum/1 mm of axial length, and 3 mum/1 D sphere.

CONCLUSIONS:

Moderately myopic subjects tend to have thin peripapillary RNFL, mainly at the superior and inferior poles, as measured by Stratus OCT. This phenomenon should be considered when interpreting a glaucoma suspect's Stratus OCT measurements compared with the normative database.

PMID:
19745664
PMCID:
PMC2742764
DOI:
10.1097/IJG.0b013e318193c2be
[Indexed for MEDLINE]
Free PMC Article

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