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Trends Parasitol. 2009 Nov;25(11):491-4. doi: 10.1016/j.pt.2009.07.009. Epub 2009 Sep 9.

The role of specific Toxoplasma gondii molecules in manipulation of innate immunity.

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1
Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, 1550 Linden Drive, Madison, WI 53706, USA.

Abstract

Infection with the parasite Toxoplasma gondii stimulates an innate immune response in the host. T. gondii also induces alterations in infected monocytes and dendritic cells that probably contribute to its ability to disseminate and ultimately to establish persistent infection. Recent progress has linked specific parasite molecules to immune stimulation or the ability of the parasite to subvert intracellular signaling pathways in infected cells to evade immunity.

PMID:
19744886
PMCID:
PMC2771455
DOI:
10.1016/j.pt.2009.07.009
[Indexed for MEDLINE]
Free PMC Article
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