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Int J Mol Sci. 2009 Jul 6;10(7):3033-43. doi: 10.3390/ijms10073033.

Hedgehog signaling regulates the survival of gastric cancer cells by regulating the expression of Bcl-2.

Author information

  • 1Department of Anatomy, School of Medicine, Pusan National University, Korea. corsaro@paran.com

Abstract

Gastric cancer is the second most common cause of cancer deaths worldwide. The underlying molecular mechanisms of its carcinogenesis are relatively poorly characterized. Hedgehog (Hh) signaling, which is critical for development of various organs including the gastrointestinal tract, has been associated with gastric cancer. The present study was undertaken to reveal the underlying mechanism by which Hh signaling controls gastric cancer cell proliferation. Treatment of gastric cancer cells with cyclopamine, a specific inhibitor of Hh signaling pathway, reduced proliferation and induced apoptosis of gastric cancer cells. Cyclopamine treatment induced cytochrome c release from mitochondria and cleavage of caspase 9. Moreover, Bcl-2 expression was significantly reduced by cyclopamine treatment. These results suggest that Hh signaling regulates the survival of gastric cancer cells by regulating the expression of Bcl-2.

KEYWORDS:

Bcl-2; apoptosis; gastric cancer; hedgehog signaling

PMID:
19742123
PMCID:
PMC2738910
DOI:
10.3390/ijms10073033
[PubMed - indexed for MEDLINE]
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