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J Cyst Fibros. 2009 Dec;8(6):386-91. doi: 10.1016/j.jcf.2009.08.003. Epub 2009 Sep 8.

Trends in pathogens colonising the respiratory tract of adult patients with cystic fibrosis, 1985-2005.

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1
Adult Cystic Fibrosis Dept, NHLI/Imperial College and Royal Brompton Hospital, London, United Kingdom.

Abstract

INTRODUCTION:

The treatment of patients with CF has continued to evolve. We hypothesised that sputum microbiology may have changed as a result of this.

METHOD:

Retrospective analysis of sputum microbiology from adult CF patients (1985 to 2005) using the Royal Brompton Hospital CF database.

RESULTS:

Colonisation with Pseudomonas aeruginosa or Staphylococcus aureus between 1985 and 2005 remained stable (77 to 82%, p=0.159; 54 to 47%, p=0.108; respectively). Haemophilus influenzae (48 to 6%; p<0.001), Aspergillus species (18 to 9%; p=0.002) and Burkholderia cepacia complex (9 to 4%; p=0.041) prevalence decreased. Stenotrophomonas maltophilia and MRSA increased (1 to 4%, p=0.02; 1 to 6%, p=0.002, respectively).

CONCLUSION:

P. aeruginosa colonisation has remained stable; there has been a decline in B. cepacia complex, H. influenzae and Aspergillus sp., and only a small increase in S. maltophilia and MRSA. Intensive antibiotic strategies have been employed, which, so far, have not resulted in clinically significant emergence of new pathogens.

PMID:
19740710
DOI:
10.1016/j.jcf.2009.08.003
[Indexed for MEDLINE]
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