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Trends Biochem Sci. 2009 Oct;34(10):483-90. doi: 10.1016/j.tibs.2009.06.006. Epub 2009 Sep 7.

Post-translational modifications in circadian rhythms.

Author information

1
Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA.

Abstract

The pace has quickened in circadian biology research. In particular, an abundance of results focused on post-translational modifications (PTMs) is sharpening our view of circadian molecular clockworks. PTMs affect nearly all aspects of clock biology; in some cases they are essential for clock function and in others, they provide layers of regulatory fine-tuning. Our goal is to review recent advances in clock PTMs, help make sense of emerging themes, and spotlight intriguing (and perhaps controversial) new findings. We focus on PTMs affecting the core functions of eukaryotic clocks, in particular the functionally related oscillators in Neurospora crassa, Drosophila melanogaster, and mammalian cells.

PMID:
19740663
PMCID:
PMC2765057
DOI:
10.1016/j.tibs.2009.06.006
[Indexed for MEDLINE]
Free PMC Article

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