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Clin Chim Acta. 2009 Nov;409(1-2):70-4. doi: 10.1016/j.cca.2009.08.020. Epub 2009 Sep 6.

Bone turnover markers in Spanish postmenopausal women: the Camargo cohort study.

Author information

1
Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, RETICEF, Santander, Spain.

Abstract

BACKGROUND:

This cross-sectional study was performed to determine the reference ranges for two bone turnover markers--aminoterminal propeptide of type I collagen (P1NP) and C-terminal telopeptide of type I collagen (beta-CrossLaps, beta-CTX)--in normal postmenopausal Spanish women as determined in serum by automated methods.

METHODS:

A community-based population of 1080 healthy postmenopausal women was evaluated. Data regarding risk factors for osteoporosis and fractures were collected by means of a structured questionnaire. Fasting serum levels of P1NP, beta-CTX, 25-Hydroxivitamin D (25OHD), and intact parathyroid hormone (iPTH) were measured on the Elecsys 2010 automated analyzer (Roche). BMD at lumbar spine, femoral neck and total hip was determined by DXA.

RESULTS:

The mean age of subjects was 63+/-9. Logarithmic transformation of both markers was performed to allow for normal distributions. Mid-95% ranges for P1NP and beta-CTX were 19-100 ng/ml and 0.112-1.018 ng/ml, respectively. Mean values of P1NP (47.7+/-19.9 ng/ml) were similar to those previously determined by the manufacturer of the assays, whereas beta-CTX mean values (0.387+/-0.197 ng/ml) were lower. Both markers were higher among osteoporotic women.

CONCLUSIONS:

Values obtained from this well-characterized population study provide reference ranges for serum automated P1NP and beta-CTX in normal Spanish postmenopausal women.

PMID:
19737549
DOI:
10.1016/j.cca.2009.08.020
[Indexed for MEDLINE]

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