Format

Send to

Choose Destination
See comment in PubMed Commons below
Cell. 2009 Sep 4;138(5):830-2. doi: 10.1016/j.cell.2009.08.022.

The hows and Ys of genome integrity.

Author information

1
Stowers Institute for Medical Research, Kansas City, MO 64110, USA.

Abstract

Much of the Y chromosome consists of large palindromic arrays harboring genes that are critical for spermatogenesis. In this issue, Lange et al. (2009) show that although gene conversion within these arrays maintains their integrity, it also permits rare unequal sister chromatid-exchange events within palindromes that create unstable dicentric chromosomes, resulting in infertility, sex reversal, and Turner syndrome.

PMID:
19737510
DOI:
10.1016/j.cell.2009.08.022
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center