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Cell. 2009 Sep 4;138(5):830-2. doi: 10.1016/j.cell.2009.08.022.

The hows and Ys of genome integrity.

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1
Stowers Institute for Medical Research, Kansas City, MO 64110, USA.

Abstract

Much of the Y chromosome consists of large palindromic arrays harboring genes that are critical for spermatogenesis. In this issue, Lange et al. (2009) show that although gene conversion within these arrays maintains their integrity, it also permits rare unequal sister chromatid-exchange events within palindromes that create unstable dicentric chromosomes, resulting in infertility, sex reversal, and Turner syndrome.

PMID:
19737510
DOI:
10.1016/j.cell.2009.08.022
[Indexed for MEDLINE]
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