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J Med Chem. 2009 Oct 8;52(19):5789-92. doi: 10.1021/jm9010719.

Nitazoxanide kills replicating and nonreplicating Mycobacterium tuberculosis and evades resistance.

Author information

1
Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York 10065, USA.

Abstract

We report here that nitazoxanide (NTZ) and its active metabolite kill replicating and nonreplicating M. tuberculosis at low microg/mL levels. NTZ appears to evade resistance, as we were unable to recover resistant colonies, using up to 10(12) colony forming units. Therefore, NTZ is a novel lead compound that kills replicating and nonreplicating M. tuberculosis by a novel mechanism of action, which appears to bypass the development of resistance.

PMID:
19736929
DOI:
10.1021/jm9010719
[Indexed for MEDLINE]

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