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Curr Opin Drug Discov Devel. 2009 Sep;12(5):644-58.

Resolvins: Current understanding and future potential in the control of inflammation.

Author information

1
Centro Nacional de Biotecnología/CSIC, Department of Plant Molecular Genetics, Universidad Autónoma, Cantoblanco, Madrid, Spain. gbannenberg@cnb.csic.es

Erratum in

  • Curr Opin Drug Discov Devel. 2010 Jan;13(1):136.

Abstract

Research on the formation of novel enzymatic oxygenation products derived from the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) has revealed the endogenous formation of several novel autacoids that have been termed resolvins and protectins. The elucidation of the chemical structures of resolvins and protectins, and the assessment of their endogenous functions, are providing a new understanding of the role of endogenous omega-3 fatty acid-derived lipid mediators in tissue protection, counteraction of inflammation and the activation of inflammation resolution. This review emphasizes the structural aspects of resolvin biosynthesis and metabolic inactivation, which are of central importance for understanding the current and future development of therapeutically relevant, stable analogs that may activate inflammation resolution.

PMID:
19736623
[Indexed for MEDLINE]

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