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Curr Opin Drug Discov Devel. 2009 Sep;12(5):616-27.

Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential.

Author information

1
University of South Carolina, Department of Chemistry & Biochemistry, Columbia, 29208, USA.

Abstract

The protein arginine deiminases (PADs), and in particular PAD4, have emerged as potential therapeutic targets for the treatment of rheumatoid arthritis (RA). In this review, evidence linking dysregulated PAD activity to the onset and progression of RA is presented, and the potential role of such aberrant activity in other human diseases, such as multiple sclerosis and cancer, is discussed. The known physiological roles of the PADs, particularly PAD4, and current knowledge regarding PAD structure, catalysis and inhibition are also described.

PMID:
19736621
PMCID:
PMC3771078
[Indexed for MEDLINE]
Free PMC Article

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