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J Pain Symptom Manage. 2009 Sep;38(3):460-5. doi: 10.1016/j.jpainsymman.2008.10.008.

Novel use of amantadine: to treat hiccups.

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Palliative Care Team Office, Cancer Care Centre, York Hospital, York, UK.


Persistent hiccups may have a considerable impact on general health through disturbance of diet, sleep, and mood. They can cause exhaustion, malnutrition, dehydration, wound dehiscence, and even death in extreme cases. We report a complex clinical case of intractable hiccups in a patient with cancer of the pancreas and Parkinson's disease and some of the problems encountered when attempting symptom control. We also discuss a potential therapeutic response to a novel agent, amantadine, unlicensed in the treatment of hiccups.

[Indexed for MEDLINE]

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