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Nat Chem Biol. 2009 Oct;5(10):724-6. doi: 10.1038/nchembio.214. Epub 2009 Sep 6.

Augmented photoswitching modulates immune signaling.

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1
Max Planck Research Unit for Enzymology of Protein Folding, Halle, Germany.

Abstract

Reversible and non-invasive photoswitching of the immunosuppressive effect of a drug would be a very valuable tool for precisely regulating the immune system. Using a combination of protein borrowing and two-photon photoisomerization, we designed and synthesized derivatives of cyclosporin A. Here we demonstrate photoswitching of the local conformation within small molecules, which we used to modulate inhibitory potencies for cyclophilin, influence ternary and quaternary complex formations and regulate T-cell transcriptional activation in situ.

PMID:
19734911
DOI:
10.1038/nchembio.214
[Indexed for MEDLINE]
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