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Cell Stem Cell. 2009 Sep 4;5(3):244-7. doi: 10.1016/j.stem.2009.08.010.

Pluripotent stem cells and disease modeling.

Author information

1
Institute of Medical Biology, Singapore, Singapore. alan.colman@imb.a-star.edu.sg

Abstract

Human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) can theoretically be converted into any somatic cell type. hESCs and hiPSCs carrying genetic defects can now be produced to model diseases in vitro. We suggest several guiding principles to help ensure an optimal fit between technology and disease.

PMID:
19733533
DOI:
10.1016/j.stem.2009.08.010
[Indexed for MEDLINE]
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