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Cell Stem Cell. 2009 Sep 4;5(3):232-4. doi: 10.1016/j.stem.2009.08.008.

Growth signaling at the nexus of stem cell life and death.

Author information

1
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.

Abstract

Stress can activate tumor-suppressive mechanisms, causing the loss of adult stem cell function with age. In this issue of Cell Stem Cell and in Nature, Castilho et al. (2009) and Harrison et al. (2009) highlight the importance of mTOR signaling in stem cell exhaustion and mammalian aging, respectively.

PMID:
19733530
PMCID:
PMC3390250
DOI:
10.1016/j.stem.2009.08.008
[Indexed for MEDLINE]
Free PMC Article

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