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Cell Stem Cell. 2009 Sep 4;5(3):229-30. doi: 10.1016/j.stem.2009.08.007.

Getting to the root of BRCA1-deficient breast cancer.

Author information

1
Centre de Recherche en Cancérologie de Marseille, Laboratoire d'Oncologie Moléculaire, UMR891 Inserm/Institut Paoli-Calmettes, Marseille, France.

Abstract

Loss of BRCA1 has been shown to expand breast stem cells. In Nature Medicine, Lim et al. (2009) demonstrate that breast tissue from BRCA1 mutation carriers contains expanded luminal progenitor cells, suggesting a broader role for BRCA1 in mammary development.

PMID:
19733528
DOI:
10.1016/j.stem.2009.08.007
[Indexed for MEDLINE]
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