In vivo infection of IgG-containing cells by Jembrana disease virus during acute infection

Virology. 2009 Oct 25;393(2):221-7. doi: 10.1016/j.virol.2009.07.027. Epub 2009 Sep 5.

Abstract

Jembrana disease virus (JDV) is an unusual bovine lentivirus which causes a non-follicular proliferation of lymphocytes, a transient immunosuppression and a delayed humoral response in infected Bali cattle in Indonesia. A double-immunofluorescent labeling method was developed to identify the subset of mononuclear cells in which the viral capsid protein could be detected. Viral antigen was present in pleomorphic centroblast-like cells which were identified as IgG-containing cells, including plasma cells, in lymphoid tissues. There was no evidence of infection of CD3(+) T-cells or MAC387(+) monocytes in tissues but large vacuolated cells with a macrophage-like morphology in the lung were found to contain viral antigen although they could not be shown conclusively to be infected. The tropism of JDV for mature IgG-containing cells may be relevant to understanding the pathogenesis of Jembrana disease, the delayed antibody responses and the genetic composition of this atypical lentivirus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal / immunology
  • Antibodies, Viral / immunology*
  • Antigens, Viral / immunology
  • Capsid Proteins / immunology
  • Cattle
  • Cattle Diseases / immunology*
  • Cattle Diseases / virology
  • Female
  • Immunoglobulin G / immunology*
  • Lentivirus Infections / immunology
  • Lentivirus Infections / veterinary*
  • Lentivirus Infections / virology
  • Lentiviruses, Bovine / immunology*
  • Lung / immunology
  • Lung / virology
  • Lymphoid Tissue / immunology
  • Lymphoid Tissue / virology
  • Macrophages / immunology
  • Macrophages / virology
  • Monocytes / immunology
  • Monocytes / virology
  • Plasma Cells / immunology
  • Plasma Cells / virology

Substances

  • Antibodies, Monoclonal
  • Antibodies, Viral
  • Antigens, Viral
  • Capsid Proteins
  • Immunoglobulin G