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Am J Obstet Gynecol. 2009 Sep;201(3):281.e1-9. doi: 10.1016/j.ajog.2009.06.041.

A maternal high-fat diet is accompanied by alterations in the fetal primate metabolome.

Author information

1
Metabolomics Core Research Facility, University of Utah Health Sciences, Salt Lake City, UT, USA.

Abstract

OBJECTIVE:

To characterize the serum metabolome of a primate model of in utero high-fat exposure.

STUDY DESIGN:

Serum from maternal and fetal (e130) macaque monkeys exposed to either a high-fat or control diet were analyzed by gas chromatography-mass spectrometry. Multivariate data analysis was performed to reduce the generated data set. Candidate metabolites were further analyzed for significance by using the analysis of variance and comparative t tests.

RESULTS:

Approximately 1300 chromatographic features were detected. Through multivariate data analysis this number was reduced to 60 possible metabolites. With the use of comparative t tests, 22 metabolites had statistical significance (P < .05) over the entire study. By virtue of maternal high-fat diet alone, fetal phenotypic differences are accompanied by altered metabolite concentrations of 7 metabolites (P < .05).

CONCLUSION:

In utero high-fat diet exposure is associated with an altered fetal epigenome and parlays a characteristic modification in the fetal metabolite profile.

PMID:
19733280
PMCID:
PMC2749563
DOI:
10.1016/j.ajog.2009.06.041
[Indexed for MEDLINE]
Free PMC Article

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