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Fertil Steril. 2010 Jan;93(1):304-6. doi: 10.1016/j.fertnstert.2009.07.992. Epub 2009 Sep 3.

Caffeine consumption and miscarriage: a prospective cohort study.

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  • 1Epidemiology Branch, Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Rockville, Maryland 20852, USA.


Caffeine consumption has been equivocally associated with miscarriage, despite an absence of prospective longitudinal measurement of caffeine intake during sensitive windows of human development. In response to this critical data gap, we analyzed daily caffeine consumption while attempting pregnancy through 12 menstrual cycles at risk for pregnancy and found that caffeine consumption did not increase the risk or hazard of miscarriage, even after adjusting for relevant covariates.

Copyright 2010 American Society for Reproductive Medicine. All rights reserved.

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