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Cancer Cell. 2009 Sep 8;16(3):180-2. doi: 10.1016/j.ccr.2009.08.013.

SDH5 mutations and familial paraganglioma: somewhere Warburg is smiling.

Author information

1
Howard Hughes Medical Institute, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA 02115, USA. william_kaelin@dfci.harvard.edu

Abstract

Paragangliomas have been linked to mutations affecting the succinate dehydrogenase complex. In a recent issue of Science, Rutter and coworkers showed that SDH5 is required for the flavination of SDHA, which is necessary for SDH assembly and function. Moreover, they detected SDH5 mutations in a large kindred with familial paraganglioma.

PMID:
19732718
DOI:
10.1016/j.ccr.2009.08.013
[Indexed for MEDLINE]
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