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Cancer Cell. 2009 Sep 8;16(3):174-6. doi: 10.1016/j.ccr.2009.08.012.

Imatinib resistance and progression of CML to blast crisis: somatic hypermutation AIDing the way.

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1
Yale Cancer Center, Department of Internal Medicine, Section of Hematology, Yale University School of Medicine, New Haven, CT 06520, USA.

Abstract

Very little is known about how acquired oncogenic mutations arise. In this issue of Cancer Cell, Klemm and colleagues present evidence supporting a role for the antibody diversification enzyme activation-induced deaminase (AID) in the generation of mutations associated with disease progression and drug resistance in chronic myeloid leukemia.

PMID:
19732715
DOI:
10.1016/j.ccr.2009.08.012
[Indexed for MEDLINE]
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