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Cancer Cell. 2009 Sep 8;16(3):173-4. doi: 10.1016/j.ccr.2009.08.014.

The yin-yang of tumor-associated neutrophils.

Author information

1
Istituto Clinico Humantas IRCCS and Department of Translational Medicine, University of Milan, Milan, Italy. alberto.mantovani@humanitas.it

Abstract

Cancer-related inflammation is a key component of the tumor microenvironment. A report in this issue of Cancer Cell now indicates that tumor-associated neutrophils in lung cancer can polarize to either "N1" or "N2" phenotype that inhibits or promotes cancer development, respectively.

PMID:
19732714
DOI:
10.1016/j.ccr.2009.08.014
[Indexed for MEDLINE]
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