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Nucleic Acids Res. 1977;4(5):1539-52.

Rates of formation and thermal stabilities of RNA:DNA and DNA:DNA duplexes at high concentrations of formamide.

Abstract

The thermal stabilities of RNA:DNA hybrids are substantially greater than those of DNA:DNA duplexes in aqueous electrolyte solutions containing high concentrations of formamide. Association rates to form DNA:DNA duplexes and DNA:RNA hybrids have been measured in these solvents. There is a temperature range in which DNA:DNA rates are negligible and RNA:DNA rates close to optimal.

PMID:
19730
PMCID:
PMC343772
DOI:
10.1093/nar/4.5.1539
[Indexed for MEDLINE]
Free PMC Article

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