Format

Send to

Choose Destination
See comment in PubMed Commons below
Mol Aspects Med. 2009 Dec;30(6):397-405. doi: 10.1016/j.mam.2009.08.005. Epub 2009 Sep 1.

The genome and variation of Bacillus anthracis.

Author information

1
The Microbial Genetics and Genomics Center, Northern Arizona University, Flagstaff AZ 86011-4073, USA. Paul.Keim@nau.edu

Abstract

The Bacillus anthracis genome reflects its close genetic ties to Bacillus cereus and Bacillus thuringiensis but has been shaped by its own unique biology and evolutionary forces. The genome is comprised of a chromosome and two large virulence plasmids, pXO1 and pXO2. The chromosome is mostly co-linear among B. anthracis strains and even with the closest near neighbor strains. An exception to this pattern has been observed in a large inversion in an attenuated strain suggesting that chromosome co-linearity is important to the natural biology of this pathogen. In general, there are few polymorphic nucleotides among B. anthracis strains reflecting the short evolutionary time since its derivation from a B. cereus-like ancestor. The exceptions to this lack of diversity are the variable number tandem repeat (VNTR) loci that exist in genic and non genic regions of the chromosome and both plasmids. Their variation is associated with high mutability that is driven by rapid insertion and deletion of the repeats within an array. A notable example is found in the vrrC locus which is homologous to known DNA translocase genes from other bacteria.

PMID:
19729033
PMCID:
PMC3034159
DOI:
10.1016/j.mam.2009.08.005
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center