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J Mol Cell Cardiol. 2010 Mar;48(3):474-82. doi: 10.1016/j.yjmcc.2009.08.024. Epub 2009 Aug 31.

The extracellular matrix: at the center of it all.

Author information

1
Texas A&M Health Science Center College of Medicine, Division of Molecular Cardiology, 1901 South 1st Street, Building 205, Room 1R24, Temple, TX 76504, USA.

Abstract

The extracellular matrix is not only a scaffold that provides support for cells, but it is also involved in cell-cell interactions, proliferation and migration. The intricate relationships among the cellular and acellular components of the heart drive proper heart development, homeostasis and recovery following pathological injury. Cardiac myocytes, fibroblasts and endothelial cells differentially express and respond to particular extracellular matrix factors that contribute to cell communication and overall cardiac function. In addition, turnover and synthesis of ECM components play an important role in cardiac function. Therefore, a better understanding of these factors and their regulation would lend insight into cardiac development and pathology, and would open doors to novel targeted pharmacologic therapies. This review highlights the importance of contributions of particular cardiac cell populations and extracellular matrix factors that are critical to the development and regulation of heart function.

PMID:
19729019
PMCID:
PMC2824065
DOI:
10.1016/j.yjmcc.2009.08.024
[Indexed for MEDLINE]
Free PMC Article

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