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Nature. 1990 Jun 21;345(6277):686-92.

A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo.

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1
Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20892.

Abstract

The murine oct-3 gene encodes a transcription factor containing a POU-specific domain and a homeodomain. In marked contrast to other homeodomain-encoding genes, oct-3 is expressed in the totipotent and pluripotent stem cells of the pregastrulation embryo and is down-regulated during differentiation to endoderm and mesoderm, suggesting that it has a role in early development. The oct-3 gene is also expressed in primordial germ cells and in the female germ line.

PMID:
1972777
DOI:
10.1038/345686a0
[Indexed for MEDLINE]
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