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Beijing Da Xue Xue Bao Yi Xue Ban. 2009 Aug 18;41(4):456-8.

Clinical study of transplantation of neural stem cells in therapy of inherited cerebellar atrophy.

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Department of Neurosurgery, General Hospital of Navy, Beijing 100048, China.



To study the clinical effect of neural stem cell transplantation in the treatment of inherited cerebellar atrophy (CA).


The cells from human fetal cerebellum (8-10 weeks of gestation) were grown and expanded in vitro. The cultured neurospheres were then planted into the dentate nuclei of patients by stereo tactic operation. Totally, 12 patients (7 males and 5 females with age ranging 22-62 years, mean 43 years) were treated by this operation from August 2006 to August 2008.


The cells of fetal cerebellum were expanded by 10(7) folds in undifferentiated state in the culture. After the operation, no rejection was detected. Follow up, the effective rates were 58.3% after 3 months, 75.0% after 6 months, and 66.7% for 12-24 months (mean 18 months).


The transplantation of in vitro cultured neural stem cell is a feasible and effective treatment for inherited CA, but the long term effectiveness need to be taken in consideration.

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