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J Clin Invest. 2009 Sep;119(9):2528-31. doi: 10.1172/JCI40555. Epub 2009 Aug 24.

Defining a role for the homeoprotein Six1 in EMT and mammary tumorigenesis.

Author information

1
Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida 32224, USA. radisky.derek@mayo.edu

Abstract

Homeobox (Hox) genes encode transcription factors that act as critical regulators of growth and differentiation during embryogenesis. While many studies have identified increased expression of Hox genes in tumors, much less is known about the mechanistic basis by which Hox genes facilitate tumor development. In this issue of the JCI, McCoy and colleagues show that transgenic mice that express the homeoprotein Six1 in mammary epithelial cells show increases in stem/progenitor cell populations and subsequent tumor development, while in a separate study Micalizzi and colleagues show that overexpression of Six1 facilitates breast cancer cell metastasis by inducing epithelial-mesenchymal transition (EMT) (see the related articles beginning on pages 2663 and 2678, respectively). Their findings implicate Six1 as a central mediator of breast cancer development.

PMID:
19726879
PMCID:
PMC2735897
DOI:
10.1172/JCI40555
[Indexed for MEDLINE]
Free PMC Article
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