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J Clin Invest. 2009 Sep;119(9):2535-7. doi: 10.1172/JCI40598. Epub 2009 Aug 24.

Pass the bicarb: the importance of HCO3- for mucin release.

Author information

1
Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, Kansas 66160, USA. rdelisle@kumc.edu

Abstract

Accumulation of thick, sticky mucus is a hallmark of the genetic disease cystic fibrosis (CF) and has a central role in CF pathophysiology. Mutations in the CF transmembrane regulator (CFTR) ion channel are known to result in abnormally thick and sticky mucus; however, why mucus accumulates in CF is still not completely understood. In this issue of the JCI, Garcia and colleagues show that mucin--the heavily glycosylated protein contained within mucus--requires CFTR and bicarbonate in order to be released from mouse intestine (see the related article beginning on page 2613). The authors propose a model whereby CFTR-mediated bicarbonate secretion must be concurrent with mucin exocytosis for proper mucin release.

PMID:
19726878
PMCID:
PMC2735941
DOI:
10.1172/JCI40598
[Indexed for MEDLINE]
Free PMC Article

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