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J Immunol. 2009 Sep 15;183(6):3561-7. doi: 10.4049/jimmunol.0800933.

B cell receptor and BAFF receptor signaling regulation of B cell homeostasis.

Author information

1
Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. wnkhan@med.miami.edu

Abstract

B lymphocyte homeostasis depends on tonic and induced BCR signaling and receptors sensitive to trophic factors, such as B cell-activating factor receptor (BAFF-R or BR3) during development and maintenance. This review will discuss growing evidence suggesting that the signaling mechanisms that maintain B cell survival and metabolic fitness during selection at transitional stages and survival after maturation rely on cross-talk between BCR and BR3 signaling. Recent findings have also begun to unravel the molecular mechanisms underlying this crosstalk. In this review I also propose a model for regulating the amplitude of BCR signaling by a signal amplification loop downstream of the BCR involving Btk and NF-kappaB that may facilitate BCR-dependent B cell survival as well as its functional coupling to BR3 for the growth and survival of B lymphocytes.

PMID:
19726767
DOI:
10.4049/jimmunol.0800933
[Indexed for MEDLINE]
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