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J Mol Cell Biol. 2009 Dec;1(2):66-8. doi: 10.1093/jmcb/mjp016. Epub 2009 Sep 2.

BATF: bringing (in) another Th17-regulating factor.

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Department of Immunology and Center for Cancer Immunology Research, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.


T helper (Th) 17 cells are a recently identified subset of T cells that regulate tissue inflammation, and RORgammat and RORalpha have been shown to be Th17-specific transcription factors that mediate Th17 cell generation. A new study of Batf-deficient mice shows that this AP-1 family transcription factor also regulates Th17 cell differentiation by binding to Th17-associated gene promoters and by maintaining RORalpha and RORgammat expression, shedding new lights on current clinical modulation of Th17 cell function in inflammatory diseases.

[Indexed for MEDLINE]

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