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J Biomed Opt. 2009 Jul-Aug;14(4):044012. doi: 10.1117/1.3183805.

Infrared-based third and second harmonic generation imaging of cornea.

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National Taiwan University, Graduate Institute of Photonics and Optoelectronics, Department of Electrical Engineering, No 1 Roosevelt Road Section 4, Taipei 10617, Taiwan.


The cornea functions as an optical lens and plays an important role in vision. For corneal diagnosis and treatment such as refractive surgery, a microscopic imaging system with a 3-D cellular resolution and retinal safety is strongly desired. Recently, confocal and multiphoton microscopies have been applied to corneal imaging with visible to near-infrared light sources. To increase retinal safety, an infrared light source is be needed. In this work, an infrared-based third and second harmonic generation microscopic study of mouse eyes is reported with approximately 700-mum penetrability and high cellular resolution. This study provides a critical reference for future development of infrared-based corneal imaging.

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