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J Periodontol. 2009 Sep;80(9):1493-7. doi: 10.1902/jop.2009.090128.

Local delivery of hyaluronan as an adjunct to scaling and root planing in the treatment of chronic periodontitis.

Author information

1
Dental Hygiene Program and Department of Periodontology, Institute of Odontology, Karolinska Institute, Huddinge, Sweden. annsofi.johannsen@ki.se

Abstract

BACKGROUND:

The aim of the present study was to evaluate the adjunctive effect of the local application of a hyaluronan gel to scaling and root planing in the treatment of chronic periodontitis.

METHODS:

Twelve patients with chronic periodontitis were recruited to participate in a study with a split-mouth design and provided informed consent. Plaque formation and bleeding on probing were evaluated pretreatment (baseline) and at 1, 4, and 12 weeks post-treatment. Probing depths and attachment levels were evaluated at baseline and at 12 weeks. The patients received full-mouth scaling and root planing. A hyaluronan gel was administered subgingivally in the test sites at baseline and after 1 week. Significant differences between test and control were evaluated using the paired t test, repeated-measures analysis of variance (Wilks lambda), and a non-parametric Wilcoxon signed-rank test.

RESULTS:

A significant reduction in bleeding on probing scores and probing depths was observed in both groups at 12 weeks (P <0.05). Significantly lower bleeding on probing scores were observed in the hyaluronan group compared to control at 12 weeks (P <0.05). Mean probing depth reductions between baseline and 12 weeks were 1.0 +/- 0.3 mm and 0.8 +/- 0.2 mm for the hyaluronan and control groups, respectively. The difference between the groups was statistically significant (P <0.05).

CONCLUSION:

The local application of hyaluronan gel in conjunction with scaling and root planing may have a beneficial effect on periodontal health in patients with chronic periodontitis.

PMID:
19722800
DOI:
10.1902/jop.2009.090128
[Indexed for MEDLINE]

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