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Commun Integr Biol. 2009 Jul;2(4):337-40.

The Elmo family forms an ancient group of actin-regulating proteins.

Author information

1
Laboratory of Immunogenetics Imaging Facility; National Institutes of Health; Rockville, MD USA.

Abstract

The Elmo protein family members are important mediators of small G protein activity, regulating actin-mediated processes such as chemotaxis and engulfment. Until recently,1 Elmo function has not been explored in professional phagocytes such as Dictyostelium discoideum. We discuss the significance of this family with respect to pathways that regulate Rac signaling, we present a comparison of Elmo proteins between representative taxa, and discuss our findings on ElmoA, one of six Elmo proteins found in D. discoideum.

KEYWORDS:

Dictyostelium; Elmo; TIRFM; actin; chemotaxis; myosin; small G-protein

PMID:
19721884
PMCID:
PMC2734041
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