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Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15768-73. doi: 10.1073/pnas.0906894106. Epub 2009 Aug 31.

Generation of pluripotent stem cells from patients with type 1 diabetes.

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1
Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.

Abstract

Type 1 diabetes (T1D) is the result of an autoimmune destruction of pancreatic beta cells. The cellular and molecular defects that cause the disease remain unknown. Pluripotent cells generated from patients with T1D would be useful for disease modeling. We show here that induced pluripotent stem (iPS) cells can be generated from patients with T1D by reprogramming their adult fibroblasts with three transcription factors (OCT4, SOX2, KLF4). T1D-specific iPS cells, termed DiPS cells, have the hallmarks of pluripotency and can be differentiated into insulin-producing cells. These results are a step toward using DiPS cells in T1D disease modeling, as well as for cell replacement therapy.

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PMID:
19720998
PMCID:
PMC2735559
DOI:
10.1073/pnas.0906894106
[Indexed for MEDLINE]
Free PMC Article

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